Dr. David Sinclair, Ph.D.

A renowned authority on the genetics of aging and longevity, author, and host of Lifespan with Dr. David Sinclair podcast.

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Dr. David A. Sinclair, AO, Ph.D., is a lecturer in the Department of Genetics at Harvard Medical School and co-director of the Paul F Dr. Paul F Glenn Center for Biology of Aging Research at Harvard Medical School.

Dr. David Sinclair is an expert on aging and its effects. He received his Ph.D. in Molecular Genetics from the University of New South Wales, Sydney in 1995 and has dedicated his career to understanding why we age and how we can slow down the process.

After working with Dr. Leonard Guarente at M.I.T., where they discovered a cause of yeast aging as well as the role played by Sir2 in epigenetic changes brought on by genome instability, he was recruited to Harvard Medical School in 1999. There, he has been teaching aging biology and translational medicine for 16 years now.

His main area of research is sirtuins, enzymes that change proteins in response to NAD+ level changes or caloric restriction (CR). He is also interested in chromatin, energy metabolism, mitochondria, learning and memory, neurodegeneration, and cancer.

Dr. Sinclair is a co-founder of several biotechnology firms (Sirtris, Ovascience, Genocea, Cohbar, MetroBiotech, ArcBio) as well as a director of several more.

He also serves as co-editor and co-chief editor of the journal Aging. His research has been covered in five books and two documentary films.

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