Extracellular Matrix


The extracellular matrix (ECM) is the non-cellular component of tissue that provides structural and biochemical support to the cells. It is composed of proteins, carbohydrates, and lipids that are secreted by cells and assembled into a three-dimensional network.

The ECM is constantly being remodeled in response to the needs of the cells. For example, during tissue injury, the ECM is broken down and replaced with new matrix molecules to promote healing. Similarly, during embryonic development, the ECM provides the scaffold upon which cells migrate and differentiate into various tissue types.

The composition of the ECM varies depending on the tissue type. For example, the ECM of bone is rich in collagen, while the ECM of the lung is rich in elastin. The specific composition of the ECM is important for its function in supporting and regulating cell behavior.

In addition to its structural and biochemical role, the ECM also plays an important role in cell signaling. Cells can interact with the ECM through cell surface receptors that bind to specific matrix molecules.

These interactions modulate a variety of cellular processes, including cell proliferation, differentiation, and migration.

The ECM is a dynamic and complex structure that is essential for the proper function of tissues.